• Automatic Ampoule Filler Sealer
  • Automatic Ampoule Filler Sealer

Description

Automatic Ampoule Filler Sealer from Adinath built on sturdy structure with customized options. Latest AFS series ampoule filler can handle up to 30ml glass ampoules. Machine perform ampoule loading, nitrogen purging, liquid filling, post nitrogen purging, pre heating and sealing operations. At the end filled and sealed ampoules get collected automatically onto collection tray. In tunnel operated models dead plate provided to match flow of ampoules along with connected machine. All contact parts of injectable liquid made from AISI SS 316L material to obtain cGMP compatibility.

Accurately fabricated ampoule filler machine can manage 1ml to 30ml glass ampoules with utmost precision. Machine range available for open mouth glass ampoules as well as closed mouth ampoules. Choice of filling mechanism available such as piston pump filling, servo driven filling and peristaltic pump filling. Sealing station is inbuilt feature which provides two stage sealing function. In Stage One pre heating performed to remove droplet inside ampoule tip. In Stage Two sealing operation performed by mixture of LPG and oxygen gas. 360 degree heating provided to ampoules in order to achieve perfect dome shape sealing.

Being a renowned ampoule filling and sealing machines manufacturer Adinath offers ampoule filler sealer in single head, two head, four head, six head and eight head models. We have separate range of piston pump filling models, servo driven models and peristaltic pump type models. Apart from this we have one entire range of closed ampoule filling machines. Our vision is to fabricate easy to operate and less maintenance machines on affordable price.

The Automatic Ampoule Filler is designed to meet the exacting demands of pharmaceutical manufacturing. This advanced machine ensures the precise filling and sealing of glass ampoules, adhering to stringent quality standards.

Advanced Design and Durability

Crafted with a cGMP-compliant framework, the Automatic Ampoule Filler features stainless steel contact parts. This ensures sterility and compatibility with sensitive formulations. The modular design supports easy maintenance, reducing downtime and enhancing long-term productivity.

The compact construction optimizes floor space, making it ideal for facilities with limited layouts. Additionally, it integrates seamlessly with upstream and downstream equipment, creating a streamlined production flow.

Multi-Stage Filling and Sealing Process

The Automatic Ampoule Filler employs a multi-stage process to ensure consistency and quality in every unit:

  • Infeed: Sterilized ampoules are fed onto the machine via an infeed conveyor.
  • Filling: Precision piston pumps ensure accurate liquid dosing, maintaining a filling accuracy of ±1%.
  • Nitrogen Flushing: Removes oxygen during filling, enhancing product stability and shelf life.
  • Sealing: Hermetically seals ampoules using high-temperature burners, preserving sterility.
  • Outfeed: Completed ampoules are collected for downstream processing.

High Throughput with Superior Accuracy

Capable of filling up to 12,000 ampoules per hour, the Automatic Ampoule Filler is built for high-volume manufacturing. Its “No Ampoule – No Filling” feature ensures that operations halt in the absence of ampoules, conserving resources and preventing spillage.

Enhanced Safety and Usability

The machine incorporates safety features such as protective enclosures and an emergency stop mechanism. Operators benefit from an intuitive control panel that simplifies process adjustments and provides real-time monitoring.

Additionally, the design minimizes liquid exposure to mechanical parts, reducing the risk of contamination.

Salient Features of Automatic Ampoule Filler Sealer

  • Compact model as per cGMP standard.

  • Higher production output up to 12000 Ampoules per hour.

  • All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.

  • Minimum change over parts from 1ml to 10ml ampoule size.

  • “No Ampoule – No Filling” system.

  • Ampoule neck centering during gas flushing and filling operations.

  • Possibility of nitrogen gas flushing before, during and after filling.

  • Full accessibility allows easy maintenance.

  • Machine equipped with pre-warming station.

  • Flow Meters for regulating flames easily.

  • Minimum change over time, little maintenance, easy cleaning.

Automatic Ampoule Filler Sealer Process Operation

Empty washed & sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect one/two/four/eight ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement Pre-gassing, Filling, Post Gassing, Pre-heating & Sealing Station perform filling and sealing operations. At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine. For detailed working process please explore automatic ampoule filler video in top right section of this page.

Technical Highlights

  • Ampoule Sizes: Compatible with ampoules ranging from 1 ml to 20 ml.
  • Output Capacity: Processes up to 200 ampoules per minute.
  • Material: SS 316L for liquid contact parts, ensuring sterility.
  • Power Requirements: 3-phase, 440 Volts, 2 H.P.
  • Utility Consumption: Optimized for minimal water and air usage.

Applications Across Industries

Primarily used in pharmaceuticals, the Automatic Ampoule Filler is also valuable for cosmetics and biotechnology. Its ability to handle sterile liquid formulations makes it indispensable for vaccines, injectable drugs, and cosmetic ampoules.

Design Features of the Automatic Ampoule Filler

  1. Precision Filling: Ensures uniform dosing across batches, reducing wastage.
  2. Compact Design: Optimizes space utilization in production facilities.
  3. Energy Efficiency: Operates with low power requirements, cutting utility costs.
  4. Easy Maintenance: Modular design facilitates quick cleaning and servicing.
  5. Hygienic Operation: Minimizes human intervention, reducing contamination risks.

Benefits of Choosing the Automatic Ampoule Filler

  • High-Speed Output: Increases productivity without compromising quality.
  • Enhanced Accuracy: Maintains consistency in every ampoule filled and sealed.
  • Operational Safety: Protective features ensure safety for operators and products alike.
  • Cost Efficiency: Reduces material wastage and utility consumption.

The Automatic Ampoule Filler is an essential tool for manufacturers seeking efficiency and precision in ampoule filling and sealing. Its advanced features and robust construction make it suitable for industries requiring sterile and accurate production capabilities.

Technical Specification of Automatic Ampoule Filler Sealer

Model AFS-1 AFS-2 AFS-4 AFS-8
No. of Head Single Two Four Eight
Syringes One Double Four Eight
Ampoule Sizes 1 ml to 30 ml 1 ml to 30 ml 1 ml to 20 ml 1 ml to 20 ml
Filling Speed Up to 25 ampoules/minute Up to 50 ampoules/minute Up to 100 ampoules/minute Up to 200 ampoules/minute
Filling Precison ± 1% ± 1% ± 1% ± 1%
Filling Pump Piston Pump Piston Pump Piston Pump Piston Pump
Burner Gas LPG & Oxygen (O₂) LPG & Oxygen (O₂) LPG & Oxygen (O₂) LPG & Oxygen (O₂)
Nitrogen Arranegment Before & After Filling Before & After Filling Before & After Filling Before & After Filling
Number of Fill Nozzles One Two Four Eight
Number of Nitrogen Nozzles Two Four Eight Sixteen
Number of Sealing Burners Two Four Eight Sixteen
Power Required 0.5 H.P. 1 H.P. 1 H.P. 2 H.P.
Power Voltage 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System
Contact Parts Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L
Overall Dimension 915mm (L) x 610mm (W) x 965mm (H) approx. 915mm (L) x 760mm (W) x 965mm (H) approx. 1200mm (L) x 1070mm (W) x 965mm (H) approx. 2200mm (L) x 1400mm (W) x 1100mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

FAQ of Automatic Ampoule Filler Sealer

It handles glass ampoules from 1 ml to 30 ml (depending on the model). Single- and two-head models support up to 30 ml, while four- and eight-head models typically handle up to 20 ml.

Options include piston pump filling, servo-driven filling, and peristaltic pump filling. Standard models use piston pumps with a filling precision of ±1%.

  • AFS-1 (Single head): Up to 25 ampoules/minute
  • AFS-2 (Two head): Up to 50 ampoules/minute
  • AFS-4 (Four head): Up to 100 ampoules/minute
  • AFS-8 (Eight head): Up to 200 ampoules/minute (up to 12,000 ampoules per hour)

Sealing is a two-stage process. Stage one involves pre-heating to remove droplets from the ampoule tip. Stage two uses a mixture of LPG and oxygen gas with 360-degree heating to achieve a perfect dome-shaped hermetic seal.

All liquid contact parts are made from AISI SS 316L for cGMP compatibility and sterility. Non-contact parts are made from Stainless Steel 304.

Yes. Nitrogen gas flushing is possible before, during, and after filling to remove oxygen, enhance product stability, and improve shelf life. Models include dedicated nitrogen nozzles (e.g., two for single-head, up to sixteen for eight-head).

Key features include “No Ampoule – No Filling” system, ampoule neck centering, protective enclosures, emergency stop, flow meters for flame regulation, pre-warming station, compact cGMP-compliant design, easy maintenance, and minimum changeover parts.

Most models operate on 230 Volts, Single Phase, 50 Hertz (power can be adjusted to customer requirements). Power ratings range from 0.5 H.P. (single head) to 2 H.P. (eight head).

It is primarily used in pharmaceuticals for sterile injectable liquids, vaccines, and drugs. It is also suitable for cosmetics and biotechnology applications involving sterile liquid formulations.