Description
Sterile Powder Filling Machine is suitable to fill sterile powder into vials. The precision built welded steel frame is encompassed with stainless steel sheets with access doors for servicing the machine. All parts coming in contact with container, powder and rubber stopper or exposed to the atmosphere are made of stainless steel for long life.
Salient Features of Sterile Powder Filling Machine
Process Operation of Sterile Powder Filling Machine
The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.
Technical Specification of Sterile Powder Filling Machine
| Models | APF 12S | APF 12D |
| Production Output | Up to 100 vials/minute | Up to 200 vials/minute |
| Fill Volume | 50 mg. to 10grams | 50 mg. to 10 grams |
| Vial Size | 5ml to 250ml | 5ml to 250ml |
| Filling Accuracy | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder |
| Power Load | 3.5 H. P. | 4.5 H. P. |
| Overall Dimension | 2600mm (L) X 1100mm (W) X 1800mm (H) approx. | 3000mm (L) X 1100mm (W) X 1800mm (H) approx. |
| Net Weight | 500 kgs. approx. | 700 kgs. approx. |
| Gross Weight | 750 kgs. approx. | 950 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
FAQ of Sterile Powder Filling Machine
What are the key features of Adinath’s Sterile Powder Filling Machine?
It is a compact cGMP model with a “No Vial, No Filling” system, multiple dosing capability, built-in rubber stoppering unit, individual drives for filling and sealing, variable frequency drive for speed control, safety clutch, digital production counter, and easily removable contact parts for autoclaving/sterilization.
How does the “No Vial, No Filling” system work and why is it important?
The system prevents the machine from dispensing powder when no vial is present under the filling station. This eliminates wastage of expensive sterile powder and improves process efficiency and cost control.
What filling accuracy can be expected?
The machine offers high volumetric filling accuracy. Technical specifications indicate ±2–3% in single dosing (depending on the consistency and uniformity of the bulk density of the injectable powder). Some descriptions also reference ±1% under ideal uniform-density conditions.
What is the production output of the available models?
- Model APF 12S: up to 100 vials per minute
- Model APF 12D: up to 200 vials per minute
What fill volumes and vial sizes does the machine support?
It can fill from 50 mg to 10 grams of powder into vials ranging from 5 ml to 250 ml.
How does the powder filling process work?
Sterilized powder is stored in a hopper and agitated for uniform density. A powder wheel with pistons and vacuum draws precise volumes of powder. Excess powder is removed by a doctor blade. When the port reaches the vial, low-pressure sterile air or nitrogen flushes the powder into the container. Filled vials then proceed to the built-in rubber stoppering station.
Does the machine include rubber stoppering?
Yes. It features a built-in rubber stoppering unit that saves space in the sterile area, reduces the required length of laminar flow, and securely places sterilized, siliconized rubber stoppers onto the filled vials using vibratory feeding, timing belts, and pressing rollers.
What materials are used and how is cleanability ensured?
All parts that contact the powder, containers, or rubber stoppers (or that are exposed to the atmosphere) are made of stainless steel. Contact parts are designed for easy removal to facilitate mandatory autoclaving or sterilization. The machine uses a stainless-steel square-pipe frame structure to minimize vibration.
What are the power requirements and approximate dimensions/weights of the models?
- APF 12S: 3.5 HP, approx. 2600 mm (L) × 1100 mm (W) × 1800 mm (H), net weight ~500 kg / gross ~750 kg
- APF 12D: 4.5 HP, approx. 3000 mm (L) × 1100 mm (W) × 1800 mm (H), net weight ~700 kg / gross ~950 kg
Power voltage can be adjusted according to the customer’s local supply requirements.
