Injectable Powder Filling & Rubber Stoppering Machine

Automatic Injectable Powder Filling & Rubber Stoppering Machine having eight ports in a powder wheel. The precision built welded steel frame is encompassed with stainless steel sheets with access doors for servicing the machine. Adinth offers two models in this machine, first is Automatic Single Wheel Injectable Powder Filling & Stoppering Machine which provides output up to 7000 vials/hour and second is Automatic Double Wheel Injectable Powder Filling & Stoppering Machine provides output up to 14000 vials/hour. All contact parts made for Good house keeping and complies as per current good manufacturing practice (cGMP).

The Injectable Powder Filling Machine ensures accuracy, sterility, and efficiency in pharmaceutical production. Designed for sterile powders, this machine meets stringent industry standards and integrates seamlessly into high-demand manufacturing environments.

Built with a compact, cGMP-compliant design, the Injectable Powder Filling Machine features stainless steel contact parts for sterility and durability. Its modular construction simplifies maintenance, while the compact layout saves valuable production floor space.

The machine uses advanced vacuum and pneumatic systems to transfer powder with minimal loss. This ensures product integrity and eliminates contamination risks, making it suitable for sensitive pharmaceutical applications.

Multi-Stage Powder Filling Process

The Injectable Powder Filling Machine operates through a carefully designed multi-stage process to ensure precision:

1. Vial Feeding: Sterilized vials are fed into the system via an infeed conveyor.
2. Powder Dosing: Volumetric dosing ensures accurate filling for powders with uniform densities.
3. Rubber Stoppering: A built-in unit seals vials with rubber stoppers to maintain sterility.

*Each stage is programmable, which guarantees flexibility for different batch sizes and powder types.

High Throughput and Accuracy

Capable of processing up to 120 vials per minute, the Injectable Powder Filling Machine is ideal for large-scale production. It delivers filling accuracy within ±1%, ensuring consistency in every vial. The “No Vial – No Filling” feature prevents wastage, activating the dosing mechanism only when a vial is correctly positioned.

Enhanced Operator Safety and Hygiene

Safety features include protective enclosures, emergency stop buttons, and minimal operator intervention requirements. The design emphasizes cleanroom compatibility, minimizing particle generation during operation. This ensures compliance with sterility and safety protocols.

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.

• Filling Range: Configurable for 50 mg to 1.5 grams per dose.
• Output Capacity: Processes 30 to 120 vials per minute, depending on model configuration.
• Dosing Accuracy: ±1% for powders with uniform density.
• Material: SS 316L for contact parts, SS 304 for the main frame.
• Power Requirement: 3-phase, 440 Volts, 2 H.P.
• Utility Usage: Optimized for low air and power consumption.

Applications Across Industries

The Injectable Powder Filling Machine is a crucial tool in the pharmaceutical sector for filling antibiotics, vaccines, and lyophilized powders. Its ability to handle sterile powders makes it indispensable for products requiring the highest quality standards.

Features of the Injectable Powder Filling Machine

1. Volumetric Dosing: Maintains precision in every vial with adjustable filling parameters.
2. Built-in Stoppering: Ensures airtight seals, preserving product sterility.
3. Compact Layout: Saves space in sterile production areas.
4. Energy Efficiency: Reduces power consumption, lowering operational costs.
5. User-Friendly Interface: Simplifies operation and monitoring for staff.

Benefits of Choosing the Injectable Powder Filling Machine

• Consistency: Ensures accurate dosing, reducing product rejections.
• Flexibility: Adapts to a range of vial sizes and powder types.
• Efficiency: High-speed operation meets demanding production schedules.
• Reduced Waste: Minimizes powder loss and ensures cleanroom compliance.

The Injectable Powder Filling Machine combines precision, efficiency, and reliability for sterile powder handling. Its advanced features and robust construction make it a vital asset for pharmaceutical manufacturers striving for the highest quality standards.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.