• Automatic Vial Powder Filling Machine
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Description

Automatic Vial Powder Filling Machine APF 12 is suitable to fill injectable powder in glass vials with speed up to 200 Vials per minute. All parts coming in contact with container, powder and rubber stopper or exposed to the atmosphere are made of AISI SS 316L as per regulatory requirements. Vial Filling Machine is equipped with Twelve Port Powder Wheel which works on vacuum suction technology for filling process. In built stoppering unit fix rubber stoppers immediately after powder filling. Filled and stoppered vials transfers onto cap sealing machine or swing conveyor as per process requirements. Sampling system provided to take random samples during the production. Infeed and outfeed turn tables provided on machine platform itself with speed adjustment function. Suitable size HMI screen conveniently placed onto control panel for ease of operation. As per customer’s need we offer Vial Powder Filling Machine in Single Powder Wheel, Double Powder Wheel, 8 Port Powder Wheel and 12 Port Powder Wheel Options. Needless to say all these machine models equipped with Servo based indexing mechanism which makes it suitable choice for any pharmaceutical need. 

Salient Features of Vial Powder Filling Machine

  • Compact cGMP model.

  • “No Vial, No Filling” system eliminates wastage of costly powder.

  • Suitable to fill up to 200 vials per minute.

  • Multiple Dosing System.

  • High Volumetric Filling Accuracy of ±1% of uniform density Injectable powder can be

  • Built-in Rubber Stoppering Unit saves lot of space in the Sterile Area & reduces the length of Laminar Flow.

  • Individual drive for the filling & sealing to match the speed of filling & sealing.

  • All motors are provided with appropriate contractors and relays for the protection against any overload or jamming.

  • Safety clutch system to avoid Bottle breakage.

  • Variable Frequency Drive for speed control.

  • All contact parts are easily removable for mandatory Autoclaving/ Sterilization.

  • S.S. square pipe frame structure to avoid vibration.

  • Digital counter for counting production output.

Process Operation of Vial Filling Machine

The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.

Technical Specification of Vial Powder Filling Machine

Models APF 12S APF 12D
Production Output Up to 100 vials/minute Up to 200 vials/minute
Fill Volume 50 mg. to 10grams 50 mg. to 10 grams
Vial Size 5ml to 250ml 5ml to 250ml
Filling Accuracy ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder
Power Load 3.5 H. P. 4.5 H. P.
Overall Dimension 2600mm (L) X 1100mm (W) X 1800mm (H) approx. 3000mm (L) X 1100mm (W) X 1800mm (H) approx.
Net Weight 500 kgs. approx. 700 kgs. approx.
Gross Weight 750 kgs. approx. 950 kgs. approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

FAQ of Automatic Vial Powder Filling Machine

It handles fill volumes from 50 mg to 10 grams and glass vials ranging from 5 ml to 250 ml.

Filling accuracy is ±2–3% in single dosing (depending on the consistency and uniformity of the bulk density of the injectable powder). Some descriptions also note high volumetric accuracy of ±1% for uniform-density powder.

It uses a multi-port powder wheel (options include 8-port or 12-port) that operates on vacuum suction technology. Precise powder volume is drawn into the ports via vacuum and then dispensed using sequential low-pressure compressed air or nitrogen.

Yes. It features a built-in rubber stoppering unit that applies sterilized, siliconized rubber stoppers immediately after powder filling, saving space in the sterile area and reducing the length of laminar flow required.

All parts that come into contact with the container, powder, or rubber stopper (or are exposed to the atmosphere) are made of AISI SS 316L stainless steel to meet regulatory requirements. Contact parts are easily removable for autoclaving/sterilization.

Key features include a “No Vial, No Filling” system to prevent powder wastage, a safety clutch to avoid vial breakage, individual drives for filling and sealing, motor protection against overload/jamming, and a Variable Frequency Drive (VFD) for speed control.

Sterilized powder is stored in a hopper and agitated for consistent bulk density. The powder wheel ports fill under vacuum; excess powder is removed by an adjustable doctor blade. The filled ports then index over the vials, where low-pressure air/nitrogen ejects the powder. Multiple dosing is supported.

Models include APF 12S and APF 12D (with single/double powder wheel options and 8- or 12-port wheels). Approximate dimensions are 2600 mm (L) × 1100 mm (W) × 1800 mm (H) for APF 12S and 3000 mm (L) × 1100 mm (W) × 1800 mm (H) for APF 12D. Power loads are 3.5 HP and 4.5 HP respectively.

Yes. It is a compact cGMP model with servo-based indexing, an HMI control panel, digital production counter, infeed/outfeed turntables, sampling capability, and all contact parts designed for easy sterilization—making it appropriate for injectable powder filling in regulated pharma settings.

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