Description
Automatic Injectable Powder Filling & Rubber Stoppering Machine having eight ports in a powder wheel. The precision built welded steel frame is encompassed with stainless steel sheets with access doors for servicing the machine. Adinth offers two models in this machine, first is Automatic Single Wheel Injectable Powder Filling & Stoppering Machine which provides output up to 7000 vials/hour and second is Automatic Double Wheel Injectable Powder Filling & Stoppering Machine provides output up to 14000 vials/hour. All contact parts made for Good house keeping and complies as per current good manufacturing practice (cGMP).
Salient Features of Dry Powder Filling & Rubber Stoppering Machine
Process Operation of Dry Powder Filling & Rubber Stoppering Machine
The sterilized powder is stored in powder hopper is agitated by pair of mechanical agitators for maintaining consistency and uniform bulk density. The powder wheel having eight ports rotates at the pre determined speed below the powder hopper with practically no clearance. Powder wheel consist of Piston in each port and behind the powder wheel vacuum plate is provided there is no clearance between powder wheel and vacuum plate due to back spring pressure. Precise volume of powder is sucked in to the port of powder wheel during vacuum according to the piston length different fill size can be achieved. The excess powder is doctored off by a doctor blade. Doctor blades can be adjusted from outside also without removing powder hopper. When powder wheel indexes further and remain in the port due to the vacuum till it reaches just vertically above the container. The time dose of Compressed air (Nitrogen Gas), sterilized low pressure air sequentially flushes out powder from the port of powder wheel in to the container one by one. The filled containers are immediately separated on the conveyor by vial separator and moves further for stoppering operation. (Different grooves separator can be used which depends on the container diameter or multiple dosing systems). The sterilized, siliconised, rubber stoppers stored in the vibrator bowl moves to vibratory bowl and stacked vertically in the rubber stopper chute. The container is hold firmly between pair or timing belt to pickup rubber stopper from exit end of the chute. Further the container is passed between two pressing roller for tight fit fixing of rubber stopper.
Technical Specification of Dry Powder Filling & Rubber Stoppering Machine
| Models | APF 12S | APF 12D |
| Production Output | Up to 100 vials/minute | Up to 200 vials/minute |
| Fill Volume | 50 mg. to 10grams | 50 mg. to 10 grams |
| Vial Size | 5ml to 250ml | 5ml to 250ml |
| Filling Accuracy | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder | ± 2 – 3% in single dosing depending upon consistency and uniformity of bulk density of Injectable Powder |
| Power Load | 3.5 H. P. | 4.5 H. P. |
| Overall Dimension | 2600mm (L) X 1100mm (W) X 1800mm (H) approx. | 3000mm (L) X 1100mm (W) X 1800mm (H) approx. |
| Net Weight | 500 kgs. approx. | 700 kgs. approx. |
| Gross Weight | 750 kgs. approx. | 950 kgs. approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
FAQ of Automatic Dry Powder Filling & Rubber Stoppering Machine
What models are available and what are their production outputs?
Two models are offered: APF 12S (single wheel) with output up to 100 vials/minute (approximately 7000 vials/hour) and APF 12D (double wheel) with output up to 200 vials/minute (approximately 14000 vials/hour).
What fill volumes and vial sizes does the machine support?
It handles fill volumes from 50 mg to 10 grams and vial sizes ranging from 5 ml to 250 ml for both models.
What is the filling accuracy of the machine?
Filling accuracy is ±2–3% in single dosing (or approximately ±1% as noted in features), depending on the consistency and uniformity of the bulk density of the injectable powder. Multiple dosing is also supported.
How does the powder filling process work?
Sterilized powder in the hopper is agitated for uniform density. A rotating powder wheel with pistons uses vacuum to draw precise volumes into its ports. Excess powder is removed by a doctor blade, and low-pressure sterilized air (or nitrogen) then flushes the powder into the vials.
How does the rubber stoppering operation function?
Sterilized, siliconized rubber stoppers are fed from a vibratory bowl into a chute. Filled vials are held by timing belts, pick up a stopper from the chute exit, and then pass between pressing rollers for a secure fit. Safety features include “No stopper in chute – Machine stop.”
What key safety and operational features does the machine include?
Key features include “No Vial – No Filling,” “No stopper in chute – Machine stop,” safety clutch to prevent bottle breakage, overload protection on motors, variable AC frequency drive for speed control, and all contact parts made of SS 316 for easy autoclaving/sterilization.
What are the power requirements and overall dimensions?
Power load is 3.5 HP for the APF 12S model and 4.5 HP for the APF 12D. Approximate dimensions are 2600 mm (L) × 1100 mm (W) × 1800 mm (H) for the single-wheel model and 3000 mm (L) × 1100 mm (W) × 1800 mm (H) for the double-wheel model. Power voltage can be adjusted to local requirements.
What materials and construction standards are used?
The machine has a precision-built welded steel frame covered with stainless steel sheets, an SS square pipe frame to minimize vibration, and high-quality imported gear motors. All parts contacting powder or stoppers are SS 316 and designed for cGMP compliance and easy cleaning/sterilization.
Why is the built-in rubber stoppering unit advantageous?
It significantly saves space in the sterile area and reduces the required length of laminar flow, while ensuring immediate stoppering of filled vials for better process efficiency and contamination control.
