• Closed Ampoule Filling and Sealing Machine

Description

Closed Ampoule Filling Sealing Machine or closed ampoule filler built on sturdy structure with easy to use approach. Contact areas of sterile liquid made from SS 316L material to obtain GMP compatibility. This monoblock design performs ampoule opening, filling & sealing operations on one platform.  Contact areas of sterile liquid made from AISI SS 316L material for cGMP compliance. Filling nozzles quantity depends upon model chosen and output required.

Machine suitable to handle 1ml to 10ml glass ampoules. In some models it can even fill up to 30ml big ampoules. Machine has filling capacity of 0.5ml to 30ml in single dose operation. Through different models options machine can fill up to 250 ampoules per minute. We have different types of filling mechanism options in which piston pump filling, servo driven filling and peristaltic pump filling is most common choices.

Closed ampoule filler and sealer customized to fill broad range of injectable liquids with ultimate precision. Transfer of ampoule done through slant movement of rack, during movement nitrogen purging, liquid filling, pre heating, sealing and collection operations performed. To minimize liquid wastage no ampoule – no liquid feature incorporated by default.

As a leading closed ampoule filling machine manufacturer we provide sturdy machines having quick maintenance & simple to use design. Adinath International is considered as one of leading closed ampoule filling machine exporter in India. We offers Closed Mouth Ampoule Filling Machine in Single, Two, Four, Six and Eight Head models.

Salient Features of Closed Ampoule Filling Machine

  • Compact cGMP model.

  • Higher output up to 12000 Ampoules per hour.

  • All contact parts made from High Quality Stainless Steel 316L & Non-contact parts made from Stainless Steel 304.

  • Minimum change over parts from 1ml to 10ml ampoule size.

  • “No Ampoule – No Filling” system.

  • Ampoule neck centering during gas flushing and filling operations.

  • Possibility of nitrogen gas flushing before, during and after filling.

  • Full accessibility allows easy maintenance.

  • Machine equipped with pre-warming station.

  • Flow Meters for regulating flames easily.

  • Minimum change over time, little maintenance, easy cleaning.

Process Operation of Closed Ampoule Filling Machine

Closed mouth/pre sterilized ampoules loaded onto infeed hopper of the machine. From where it has been received to receiving rack through starwheel/cassette. The moving rack which moves horizontally collect one/two/four/eight ampoules from the receiving rack and transfer the ampoule to the machine in left to right in an inclined position. During ampoule movement Pre-gassing, Filling, Post Gassing, Pre-heating & Sealing Station perform filling and sealing operations. At the end duly filled and sealed ampoules get collected automatically onto collection tray of the machine.

Technical Specification of Closed Mouth Ampoule Filling Machine

Model AFS-1C AFS-2C AFS-4C AFS-8C
No. of Head Single Two Four Eight
Syringes One Double Four Eight
Ampoule Sizes 1 ml to 30 ml 1 ml to 30 ml 1 ml to 20 ml 1 ml to 20 ml
Filling Speed Up to 25 ampoules/minute Up to 50 ampoules/minute Up to 100 ampoules/minute Up to 200 ampoules/minute
Filling Precison ± 1% ± 1% ± 1% ± 1%
Filling Pump Piston Pump Piston Pump Piston Pump Piston Pump
Burner Gas LPG & Oxygen (O₂) LPG & Oxygen (O₂) LPG & Oxygen (O₂) LPG & Oxygen (O₂)
Nitrogen Arranegment Before & After Filling Before & After Filling Before & After Filling Before & After Filling
Number of Fill Nozzles One Two Four Eight
Number of Nitrogen Nozzles Two Four Eight Sixteen
Number of Sealing Burners Two Four Eight Sixteen
Power Required 0.5 H.P. 1 H.P. 1 H.P. 2 H.P.
Power Voltage 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System
Contact Parts Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L
Overall Dimension 1050mm (L) x 610mm (W) x 965mm (H) approx. 1150mm (L) x 760mm (W) x 965mm (H) approx. 1400mm (L) x 1070mm (W) x 965mm (H) approx. 2700mm (L) x 1400mm (W) x 1100mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

FAQ of Closed Ampoule Filling and Sealing Machine

It is suitable for 1 ml to 10 ml glass ampoules, with some models filling up to 30 ml. Filling capacity ranges from 0.5 ml to 30 ml in a single dose operation, depending on the model.

Output depends on the number of heads:

  • Single head (AFS-1C): up to 25 ampoules/minute
  • Two head (AFS-2C): up to 50 ampoules/minute
  • Four head (AFS-4C): up to 100 ampoules/minute
  • Eight head (AFS-8C): up to 200 ampoules/minute Higher-output configurations can reach up to 12,000 ampoules per hour.

Common options include piston pump filling, servo-driven filling, and peristaltic pump filling. Standard models primarily use piston pumps, with filling precision of ±1%.

Key features include a compact cGMP design, all contact parts in SS 316L (non-contact in SS 304), “No Ampoule – No Filling” system, ampoule neck centering, nitrogen flushing before/during/after filling, pre-warming station, flow meters for flame regulation, minimum change-over parts (1–10 ml), easy accessibility for maintenance, and quick cleaning with low downtime.

Pre-sterilized closed ampoules are loaded into the infeed hopper and transferred via starwheel/cassette to a moving rack. The rack moves them in an inclined position while performing pre-gassing, filling, post-gassing, pre-heating, and sealing. Filled and sealed ampoules are then automatically collected on the tray.

Models include AFS-1C (1 head), AFS-2C (2 heads), AFS-4C (4 heads), and AFS-8C (8 heads). Differences cover number of syringes/nozzles, maximum ampoule size (up to 30 ml on smaller models, 20 ml on larger), speed, power requirement (0.5–2 HP), nitrogen nozzles, sealing burners, and overall dimensions.

Yes. Nitrogen gas flushing is possible before, during, and after filling. All listed models provide nitrogen arrangement before and after filling, with the number of nitrogen nozzles scaling with the number of heads (2 to 16).

Contact parts that touch sterile liquid are made from AISI SS 316L for cGMP compliance. Non-contact parts use Stainless Steel 304. The design emphasizes sterility, ease of cleaning, and minimum change-over for pharmaceutical injectable applications.

Power is typically 230 Volts, single phase, 50 Hz (adjustable to customer voltage). Burner gas uses LPG & Oxygen. Power ratings range from 0.5 HP (single head) to 2 HP (eight head). The machine includes flow meters for easy flame regulation.

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